Hybrid diffusion imaging in chronic traumatic brain injury: Longitudinal investigation and correlation with clinical outcome
Jennifer Muller1,2,3, KiChang Kang1, Devon Middleton3, Mahdi Alizadeh1, Faezeh Vedaei1, George Zabrecky4, Daniel Monti4, Nancy Wintering4, Anthony J. Bazzan4, Chengyuan Wu1, Qianhong Wu2, and Feroze B. Mohamed3
1Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, United States, 2Mechanical Engineering, Villanova University, Villanova, PA, United States, 3Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United States, 4Marcus Institute of Integrative Health, Villanova, PA, United States
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Currently, non-invasive and longitudinal assessment in TBI is still limited. In the current study, we applied an advanced hybrid diffusion imaging sequence (HYDI) to capture both diffusion tensor imaging and neurite orientation dispersion and density imaging to develop more sensitive biomarkers associated with longitudinal outcomes after TBI. We both contrasting and complementary correlates between diffusion metrics and clinical outcomes, suggesting HYDI to have potential clinical impact for treatment monitoring after TBI.
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