Abstract #1774

Hybrid diffusion imaging in chronic traumatic brain injury: Longitudinal investigation and correlation with clinical outcome

Jennifer Muller^1,2,3, KiChang Kang¹, Devon Middleton³, Mahdi Alizadeh¹, Faezeh Vedaei¹, George Zabrecky⁴, Daniel Monti⁴, Nancy Wintering⁴, Anthony J. Bazzan⁴, Chengyuan Wu¹, Qianhong Wu², and Feroze B. Mohamed³

¹Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, United States, ²Mechanical Engineering, Villanova University, Villanova, PA, United States, ³Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United States, ⁴Marcus Institute of Integrative Health, Villanova, PA, United States

Synopsis

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Currently, non-invasive and longitudinal assessment in TBI is still limited. In the current study, we applied an advanced hybrid diffusion imaging sequence (HYDI) to capture both diffusion tensor imaging and neurite orientation dispersion and density imaging to develop more sensitive biomarkers associated with longitudinal outcomes after TBI. We both contrasting and complementary correlates between diffusion metrics and clinical outcomes, suggesting HYDI to have potential clinical impact for treatment monitoring after TBI.

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