Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Currently, non-invasive and longitudinal assessment in TBI is still limited. In the current study, we applied an advanced hybrid diffusion imaging sequence (HYDI) to capture both diffusion tensor imaging and neurite orientation dispersion and density imaging to develop more sensitive biomarkers associated with longitudinal outcomes after TBI. We both contrasting and complementary correlates between diffusion metrics and clinical outcomes, suggesting HYDI to have potential clinical impact for treatment monitoring after TBI.
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