Abstract #1871

Impact Of MR Intensity Normalization For Different MR Sequences In MRI Based Radiomics Studies

Patrick Salome^1,2,3,4, Francesco Sforazzini^1,2,3,4, Andreas Kudak^3,5,6, Matthias Dostal^3,5,6, Nina Bougatf^3,5,6, Jürgen Debus^3,4,5,7, Maximilian Knoll^1,3,4,5, and Amir Abdollahi^1,3,4,5

¹CCU Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Medical Faculty, Heidelberg University Hospital, Heidelberg, Germany, ³Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany, ⁴German Cancer Consortium (DKTK) Core Center, Heidelberg, Germany, ⁵Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany, ⁶CCU Radiation Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁷National Center for Tumor Diseases (NCT), Heidelberg, Germany

Synopsis

MR-based radiomics prognostic signatures have great clinical potential but are currently hindered due to a lack of standardisation in the radiomics workflow. This study focuses on a crucial step of these workflows, i.e. intensity normalisation, while presenting a methodology that allows for determining the most suitable MR intensity normalization method for a specific entity.

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