Impact Of MR Intensity Normalization For Different MR Sequences In MRI Based Radiomics Studies
Patrick Salome1,2,3,4, Francesco Sforazzini1,2,3,4, Andreas Kudak3,5,6, Matthias Dostal3,5,6, Nina Bougatf3,5,6, Jürgen Debus3,4,5,7, Maximilian Knoll1,3,4,5, and Amir Abdollahi1,3,4,5
1CCU Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Medical Faculty, Heidelberg University Hospital, Heidelberg, Germany, 3Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany, 4German Cancer Consortium (DKTK) Core Center, Heidelberg, Germany, 5Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany, 6CCU Radiation Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany, 7National Center for Tumor Diseases (NCT), Heidelberg, Germany
MR-based radiomics prognostic signatures have great clinical potential but are currently hindered due to a lack of standardisation in the radiomics workflow. This study focuses on a crucial step of these workflows, i.e. intensity normalisation, while presenting a methodology that allows for determining the most suitable MR intensity normalization method for a specific entity.
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