Exploring Ultra-High Resolution Imaging of the Ex Vivo Whole Brain: Initial Results with Balanced Steady State Free Precession Sequences at 3T
Matthias Weigel1,2,3, Peter Dechent4, Riccardo Galbusera1,2, Erik Bahn5, Ludwig Kappos1,2, Wolfgang Brück5, Christine Stadelmann5, and Cristina Granziera1,2
1Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, 2Neurological Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, 3Dept. of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland, 4Department of Cognitive Neurology, MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany, 5Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany
Balanced steady state free precession (bSSFP) sequences provide the highest signal intensity per unti time, which makes them virtually predestined for ultra-high resolution MR imaging at 3T. Their sensitivity to susceptibility effects and demand for high performance, however, represent two major drawbacks. It will be shown that a carefully chosen protocol, which also includes common phase cycling techniques, will enable artifact-free 200-microns isotropic bSSFP acquisitions of the entire human fixed brain within approximately 27h.
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