Intracellular Acidification Monitored by Chemical Exchange Saturation Transfer MRI: Effect of Cariporide in Rat C6 Brain Tumor
Maryam Mozaffari1, Nivin Nystrom2, Alex Li2, Miranda Bellyou2, Timothy Scholl1, and Robert Bartha1
1Medical Biophysics, Western Univeristy-Robarts Reserch Institute, London, ON, Canada, 2Western Univeristy-Robarts Reserch Institute, London, ON, Canada
Our objective was to acidify rat C6 gliomas by inhibiting NHE1 with cariporide and to monitor the pH changes with AACID-CEST MRI. AACID-CEST MRI was successfully used to monitor changes in tumor pHi over time after cariporide injection. Our results showed a pH decrease in both the tumor and the contralateral tissue following cariporide injection. CEST-MRI measurement of tumor response pH could help to enhance the efficacy of this treatment paradigm in different human malignancies.
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