Abstract #2087

Intracellular Acidification Monitored by Chemical Exchange Saturation Transfer MRI: Effect of Cariporide in Rat C6 Brain Tumor

Maryam Mozaffari¹, Nivin Nystrom², Alex Li², Miranda Bellyou², Timothy Scholl¹, and Robert Bartha¹

¹Medical Biophysics, Western Univeristy-Robarts Reserch Institute, London, ON, Canada, ²Western Univeristy-Robarts Reserch Institute, London, ON, Canada

Synopsis

Our objective was to acidify rat C6 gliomas by inhibiting NHE1 with cariporide and to monitor the pH changes with AACID-CEST MRI. AACID-CEST MRI was successfully used to monitor changes in tumor pH_i over time after cariporide injection. Our results showed a pH decrease in both the tumor and the contralateral tissue following cariporide injection. CEST-MRI measurement of tumor response pH could help to enhance the efficacy of this treatment paradigm in different human malignancies.

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