Abstract #2088

Development of CEST MRI for the characterization of Alzheimer’s Disease

Fang Frank Yu¹, Natalie M Bell¹, Elizabeth M Davenport^1,2, Spencer Bowen^1,2, Brendan James Kelley³, Ivan Dimitrov^2,4, Jochen Keupp⁵, and Elena Vinogradov^1,2

¹Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Philips Healthcare, Gainseville, GA, United States, ⁵Philips Research, Hamburg, Germany

Synopsis

Alzheimer’s Disease (AD) is the leading cause of dementia, afflicting over 5 million Americans and 45 million people worldwide. We are developing CEST protocol for the characterization of abnormal protein accumulation and pathological molecular changes in AD. Our results indicate increased CEST in all frequency ranges, with the maximum around 2ppm. While preliminary, this data demonstrates CEST MRI is capable of clear differentiation between patients with AD and healthy individuals.

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