Meeting Banner
Abstract #2239

Shear stiffness measured by MR elastography correlates with compression modulus in ex vivo rat livers subjected to increasing portal pressure.

Yasmine Safraou1, Karolina Graczynska1, Tom Meyer1, Heiko Tzschätzsch1, Thomas Fischer1, Jürgen Braun1, Ingolf Sack1, and Jing Guo2
1Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany


To investigate the effect of perfusion pressure on liver stiffness, 13 ex-vivo rat livers were studied by volumetric MRI, MR elastography (MRE) and diffusion MRI under controlled portal pressures between 0 and 15 cmH2O. Liver volume, tissue-vascular volume fraction, stiffness and bulk modulus decreased while water diffusivity increased with increasing portal pressure. Collectively, our findings suggest that liver softening is caused by a relative increase in fluid volume while an increased vascular pressure, potentially increasing liver stiffness, is of minor importance when tissue can freely expand, as in our scenario.

This abstract and the presentation materials are available to members only; a login is required.

Join Here