Investigating the Repeatability of Multifrequency Magnetic Resonance Elastography applied to a Soft Gelatin Phantom
Owais Siddiqi1, Jessica Winfield1,2, Konstantinos Zormpas-Petridis1, Emma Harris1, Anand Ramkumar1, Antonio Candito1, Steffen Görner3, Christina Messiou1,2, Matthew Blackledge1, and Imogen Thrussell1,2
1Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, 2Department of Radiology, The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
New measures of response are required that can capture the inherent heterogeneity and the heterogeneous changes observed in soft tissue tumours. Shear-wave Magnetic Resonance Elastography (MRE) measures stiffness of tissue by measuring the propagation of externally applied shear waves. In this study we explore the test-retest repeatability of Multifrequency MRE (MMRE), acquired using an echo-planar imaging readout applied to a soft gelatin phantom used to mimic the stiffness of soft-tissue tumours. Our results suggest MMRE is highly repeatable and supports further investigation in using MMRE to measure response in soft-tissue tumours.
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