Abstract #2240

Investigating the Repeatability of Multifrequency Magnetic Resonance Elastography applied to a Soft Gelatin Phantom

Owais Siddiqi¹, Jessica Winfield^1,2, Konstantinos Zormpas-Petridis¹, Emma Harris¹, Anand Ramkumar¹, Antonio Candito¹, Steffen Görner³, Christina Messiou^1,2, Matthew Blackledge¹, and Imogen Thrussell^1,2

¹Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, ²Department of Radiology, The Royal Marsden NHS Foundation Trust, London, United Kingdom, ³Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

Synopsis

New measures of response are required that can capture the inherent heterogeneity and the heterogeneous changes observed in soft tissue tumours. Shear-wave Magnetic Resonance Elastography (MRE) measures stiffness of tissue by measuring the propagation of externally applied shear waves. In this study we explore the test-retest repeatability of Multifrequency MRE (MMRE), acquired using an echo-planar imaging readout applied to a soft gelatin phantom used to mimic the stiffness of soft-tissue tumours. Our results suggest MMRE is highly repeatable and supports further investigation in using MMRE to measure response in soft-tissue tumours.

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