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Abstract #2244

2D or 3D MR elastography of the brain? Answers from a 1-year follow-up study in healthy volunteers.

Helge Herthum1, Heiko Tzschätzsch1, Mehrgan Shahryari1, Bernhard Kreft1, Steffen Görner1, Stefan Hetzer2, Jürgen Braun1, and Ingolf Sack1
1Charité Universitätsmedizin Berlin, Berlin, Germany, 2Berlin Center for Advanced Neuroimaging, Berlin, Germany


MR elastography(MRE) measures in vivo soft-tissue mechanical parameters which are sensitive to various diseases. Robust and reliable measurements are critical for clinical translation; however, the variability of reported values, especially for MRE in the brain, remains a challenge. We here introduce an optimized setup for high-resolution brain MRE and compare the consistency of values obtained from 2D- and 3D-analysis in a group of healthy subjects studied in the follow-up of a year. Both 2D- and 3D-MRE values agreed very well between the two measurements. Intersubject variability was lower in 2D than in 3D while intrasubject variability was lower in 3D.

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