MR elastography(MRE) measures in vivo soft-tissue mechanical parameters which are sensitive to various diseases. Robust and reliable measurements are critical for clinical translation; however, the variability of reported values, especially for MRE in the brain, remains a challenge. We here introduce an optimized setup for high-resolution brain MRE and compare the consistency of values obtained from 2D- and 3D-analysis in a group of healthy subjects studied in the follow-up of a year. Both 2D- and 3D-MRE values agreed very well between the two measurements. Intersubject variability was lower in 2D than in 3D while intrasubject variability was lower in 3D.