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Abstract #2293

Simultaneous Assessment of Complementary Metabolic Pathways in Liver Using Co-polarized Hyperpolarized 13C pyruvate and 13C dihydroxyacetone

Yaewon Kim1, Cornelius von Morze2, Jeremy W. Gordon1, Peder E. Z. Larson1, and Michael A. Ohliger1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, 2Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, United States


Hyperpolarized 13C MRS is a powerful emerging technique for assessing metabolic liver diseases, including diabetes and fatty liver. Chemical shift separation allows monitoring of many metabolites at once. Here, we explore the possibility of co-polarizing [1-13C]pyruvate and [2-13C]dihydroxyacetone to simultaneously assess two important metabolic pathways that are altered in liver disease. Co-polarization was successful, with preserved T1 relaxation times. Although co-polarization led to modest decreases in polarization levels, all expected metabolites were observed when injected into a healthy rat. By examining two pathways at the same time, co-polarization can be an important tool for assessing liver disease.

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