Wild-type and transgenic mice derived from the C57BL/6J mouse strain are widely used in animal models of different human diseases. However, this mouse strain suffers from random appearances of sporadic congenital portosystemic shunts resulting in extremely high glutamine levels in the brain. In our recent study aimed at effects of maternal obesity on their offspring we found that in 9 out of 31 studied C57BL/6J mice had high levels of brain Gln. The purpose of this abstract is to highlight the awareness of this persisting problem in animal models based on C57BL/6J background strain.
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