Abstract #2326

Preclinical MR spectroscopy of GABA: conventional PRESS versus spectral editing with MEGAPRESS and HERMES

Diana Rotaru¹, Steve Sawiak^2,3, Camilla Simmons^1,4, Eugene Kim^1,4, Maria Elisa Serrano Navacerrada^1,4, Davide Di Censo^1,4, Adrien Le Guennec⁵, Richard Edden^6,7, David Lythgoe¹, and Diana Cash^1,4

¹Neuroimaging, King's College London, London, United Kingdom, ²Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, ³Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, ⁴BRAIN Centre (Biomarker Research And Imaging for Neuroscience), King's College London, London, United Kingdom, ⁵NMR Facility, Wolfson CARD, Guy's Campus, King's College London, London, United Kingdom, ⁶Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, United States, ⁷F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

In vivo GABA measurements with conventional (PRESS) and spectral editing methods (MEGAPRESS and HERMES) were investigated in healthy mice at 9.4 T. Animals were divided in two groups, control mice injected with saline and mice injected with Aminooxyacetic acid to intentionally elevate GABA concentration levels (n=7 per group). Our results show all three methods successfully discriminate GABA from overlapping metabolites with stronger signals. The precision of concentration estimates is more reliable for spectral editing methods given their specificity to GABA. These outcomes suggest spectral editing methods are less susceptible to systematic biases.

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