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Abstract #2326

Preclinical MR spectroscopy of GABA: conventional PRESS versus spectral editing with MEGAPRESS and HERMES

Diana Rotaru1, Steve Sawiak2,3, Camilla Simmons1,4, Eugene Kim1,4, Maria Elisa Serrano Navacerrada1,4, Davide Di Censo1,4, Adrien Le Guennec5, Richard Edden6,7, David Lythgoe1, and Diana Cash1,4
1Neuroimaging, King's College London, London, United Kingdom, 2Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, 3Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 4BRAIN Centre (Biomarker Research And Imaging for Neuroscience), King's College London, London, United Kingdom, 5NMR Facility, Wolfson CARD, Guy's Campus, King's College London, London, United Kingdom, 6Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, United States, 7F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States


In vivo GABA measurements with conventional (PRESS) and spectral editing methods (MEGAPRESS and HERMES) were investigated in healthy mice at 9.4 T. Animals were divided in two groups, control mice injected with saline and mice injected with Aminooxyacetic acid to intentionally elevate GABA concentration levels (n=7 per group). Our results show all three methods successfully discriminate GABA from overlapping metabolites with stronger signals. The precision of concentration estimates is more reliable for spectral editing methods given their specificity to GABA. These outcomes suggest spectral editing methods are less susceptible to systematic biases.

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