In this study, we investigated hyperpolarized (HP) magnetic resonance spectroscopy (MRS) as a means to identify differential lactate release in an in vitro model of epilepsy. When neurons are chronically activated, they increase LDHA expression and upregulate glycolysis as a means of cellular energy metabolism, thus increasing the production of lactate. Using MRS of HP [1-13C]pyruvate, we showed conversion to lactate in a chronic model of epilepsy. These results indicate that metabolic imaging of HP [1-13C]pyruvate can potentially be used as a tool to identify lactate elevations and thus the epileptic focus in epilepsy patients.
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