Glycogen synthase kinase 3 (GSK3) has been tied as a critical factor in the development of multiple major diseases from cancer to Alzheimer’s, but drug development has been stymied by a lack of options to detect GSK3 activity in vivo. We show here that GSK3 activity can be measured accurately in vivo by following the production of glycogen from a single bolus of unlabeled glucose on a standard 3T preclinical imaging system. Imaging of glycogen synthesis was possible at 9.4T by CSI, where it was found in mice to be centered on the olfactory bulb, as expected from post-mortem analysis
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