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Abstract #2328

Inhibition of GSK3 Activity Detected by Glycogen Synthase Activity from Proton MRS at 3T

Jeff Brender1, Shun Kishimoto1, Jeeva Munasinghe2, Helmutt Merkle2, Kota Yamashita1, Yasunori Otowa1, Kazutoshi Yamamoto1, and Murali Cherukuri Krishna1
1Radiation Biology Branch, NCI, Bethesda, MD, United States, 2NINDS, Bethesda, MD, United States


Glycogen synthase kinase 3 (GSK3) has been tied as a critical factor in the development of multiple major diseases from cancer to Alzheimer’s, but drug development has been stymied by a lack of options to detect GSK3 activity in vivo. We show here that GSK3 activity can be measured accurately in vivo by following the production of glycogen from a single bolus of unlabeled glucose on a standard 3T preclinical imaging system. Imaging of glycogen synthesis was possible at 9.4T by CSI, where it was found in mice to be centered on the olfactory bulb, as expected from post-mortem analysis

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