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Abstract #2329

High resolution Multi-voxel spectroscopy using CSI-semi-LASER for mouse brain preclinical studies

Zoona Javed1,2, Gary Martinez3, AnaPaula Candiota1,4,5, Miquel Cabanas2,4, and Silvia Lope2,4
1Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain, 2Servei de Ressonància Magnètica Nuclear, Universitat Autonoma de Barcelona, Bellaterra, Spain, 3Department of Imaging Physics, University of Texas, Houston, TX, United States, 4Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN),, Universitat Autonoma de Barcelona, Bellaterra, Spain, 5Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autonoma de Barcelona, Bellaterra, Spain


This work describes an improved multi-voxel Chemical shift imaging (CSI) pulse sequence that uses the semi-LASER localization approach. Bruker CSI sequence containing PRESS localization block (CSI-PRESS) was modified by replacing the aforementioned PRESS block with a semi-LASER one resulting in a CSI-semi-LASER sequence. This work was developed on a 7T Bruker BioSpec 70/30 USR spectrometer running ParaVision 5.1 which does not contain neither built-in blocks for semi-LASER sequence nor adiabatic pulses. The sequence was tested in wt C57/BL6 mouse brain and compared with the stock CSI-PRESS sequence. The results show improved homogeneity and reduction in chemical shift displacement error (CSDE).

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