Abstract #2329

High resolution Multi-voxel spectroscopy using CSI-semi-LASER for mouse brain preclinical studies

Zoona Javed^1,2, Gary Martinez³, AnaPaula Candiota^1,4,5, Miquel Cabanas^2,4, and Silvia Lope^2,4

¹Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain, ²Servei de Ressonància Magnètica Nuclear, Universitat Autonoma de Barcelona, Bellaterra, Spain, ³Department of Imaging Physics, University of Texas, Houston, TX, United States, ⁴Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN),, Universitat Autonoma de Barcelona, Bellaterra, Spain, ⁵Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autonoma de Barcelona, Bellaterra, Spain

Synopsis

This work describes an improved multi-voxel Chemical shift imaging (CSI) pulse sequence that uses the semi-LASER localization approach. Bruker CSI sequence containing PRESS localization block (CSI-PRESS) was modified by replacing the aforementioned PRESS block with a semi-LASER one resulting in a CSI-semi-LASER sequence. This work was developed on a 7T Bruker BioSpec 70/30 USR spectrometer running ParaVision 5.1 which does not contain neither built-in blocks for semi-LASER sequence nor adiabatic pulses. The sequence was tested in wt C57/BL6 mouse brain and compared with the stock CSI-PRESS sequence. The results show improved homogeneity and reduction in chemical shift displacement error (CSDE).

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