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Abstract #2330

Quantitative MR Imaging of Whole Intervertebral Disc: A Pre-Clinical Sample Study

Jiyo S Athertya1, Alecio F Lombardi2, Jonathan Wong2, Hyungseok Jang1, Saeed Jerban1, Jiang Du1, Koichi Masuda3, Eric Y Chang1,2, and Ya-Jun Ma1
1Radiology, University of California San Diego, San Diego, CA, United States, 2Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, 3Orthopedic Surgery, University of California San Diego, San Diego, CA, United States


Quantitative MR imaging is a powerful tool for assessing biochemical changes in tissue. In this study, we propose to measure the transverse magnetization relaxation time, diffusivity, and magnetization transfer ratio for a whole intervertebral disc (IVD), including the annulus fibrosis, cartilaginous endplate (CEP), and nucleus pulposus, on a 3T pre-clinical scanner. The sequence parameters were optimized for high resolution and high signal-to-noise ratio imaging and mapping, utilizing the high-performance gradient system on the pre-clinical scanner, and the echo times were sufficiently minimized to capture the fast-decaying CEP signals for all the quantitative imaging sequences.

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