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Abstract #2417

Probing compartment-specific diffusion in the brain with 13C diffusion-weighted MRS of hyperpolarized pyruvate and lactate: initial results

Mélissa Vincent1, Xiao Gao2,3, Myriam Chaumeil2,3, and Julien Valette1
1MIRCen / Neurodegenerative Diseases Laboratory, CEA, Fontenay-aux-Roses, France, 2Department of Physical Therapy and Rehabilitation Science, UCSF, San Francisco, CA, United States, 3Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States


Here we propose to use 13C diffusion-weighted MRS of hyperpolarized pyruvate and lactate to probe diffusion properties in distinct compartments of the mouse brain, tentatively extracellular (ECS) and intracellular spaces (ICS). Hyperpolarized 13C-pyruvate is injected intravenously and taken up by the brain before entering cells, where it is quickly converted to lactate, so that 13C-pyruvate concentration in ICS must remain low, while newly produced 13C-lactate should remain predominantly intracellular during the relatively short measurement time. We measure faster diffusion for pyruvate even after removing IVIM effect, suggesting faster diffusion in the ECS, and slow release of lactate in the ECS.

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