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Abstract #2418

Diffusion MRI protocol optimization for ex vivo mouse whole-brain tractography at 100μm isotropic resolution

Elise Cosenza1, Laurence Dallet1, Aurélien Trotier1, Emeline Ribot1, Laurent Petit2, and Sylvain Miraux1
1Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536, CNRS, Bordeaux, France, 2Groupe dImagerie Neurofonctionnelle, Institut Des Maladies Neurodegeneratives, UMR5293, CNRS, CEA University of Bordeaux, CNRS, Bordeaux, France


A protocol, including Gadolinium-DOTA perfusion or immersion and Diffusion-Weighted multi-shot Spin-Echo EPI was developed to obtain 100μm isotropic resolution tractogram on ex vivo mouse brain. A 3mM Gd-DOTA concentration combined with 16 EPI shots at short TR (400 ms) allows to whole-brain tractograms of excellent quality and reproducible on the 15 mouse brains analyzed.

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