Abstract #2418

Diffusion MRI protocol optimization for ex vivo mouse whole-brain tractography at 100μm isotropic resolution

Elise Cosenza¹, Laurence Dallet¹, Aurélien Trotier¹, Emeline Ribot¹, Laurent Petit², and Sylvain Miraux¹

¹Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536, CNRS, Bordeaux, France, ²Groupe dImagerie Neurofonctionnelle, Institut Des Maladies Neurodegeneratives, UMR5293, CNRS, CEA University of Bordeaux, CNRS, Bordeaux, France

Synopsis

A protocol, including Gadolinium-DOTA perfusion or immersion and Diffusion-Weighted multi-shot Spin-Echo EPI was developed to obtain 100μm isotropic resolution tractogram on ex vivo mouse brain. A 3mM Gd-DOTA concentration combined with 16 EPI shots at short TR (400 ms) allows to whole-brain tractograms of excellent quality and reproducible on the 15 mouse brains analyzed.

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