The way brain injury can evolve has different manifestations on imaging in multiple MRI modalities, pointing to different pathological etiologies. The true picture can be seen only by correcting for free water, as it biases all the diffusion measurements, especially the longitudinal outcome. While this has been observed in humans, it is for the first time free water analysis has been carried out in a gyrencephalic pig model of TBI. In the future, co-registration with histopathological outcomes will be undertaken to verify the specificity of the diffusion measurements, which will lay the foundation for interpretation of unbiased diffusion measurements.
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