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Abstract #2426

Free Water Imaging in a Pig Model of Traumatic Brain Injury

Drew Parker1, Victoria E. Johnson2, H. Isaac Chen2,3, John A. Wolf2,3, and Ragini Verma1
1DiCIPHR (Diffusion and Connectomics in Precision Healthcare Research) Lab, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States


The way brain injury can evolve has different manifestations on imaging in multiple MRI modalities, pointing to different pathological etiologies. The true picture can be seen only by correcting for free water, as it biases all the diffusion measurements, especially the longitudinal outcome. While this has been observed in humans, it is for the first time free water analysis has been carried out in a gyrencephalic pig model of TBI. In the future, co-registration with histopathological outcomes will be undertaken to verify the specificity of the diffusion measurements, which will lay the foundation for interpretation of unbiased diffusion measurements.

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