Abstract #2563

The vestibular neuromatrix in patients with post-concussive vestibular dysfunction and healthy controls

Jeremy Lee Smith¹, Anna Trofimova¹, Vishwadeep Ahluwalia^2,3, Jose J. Casado Garrido⁴, Julia Hurtado⁵, Rachael Frank⁵, April Hodge⁵, Russell K. Gore^4,5, and Jason W. Allen^1,4,6

¹Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ²Georgia State University, Atlanta, GA, United States, ³Center for Advanced Brain Imaging, Georgia Institute of Technology, Atlanta, GA, United States, ⁴Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, ⁵Shepherd Center, Atlanta, GA, United States, ⁶Neurology, Emory University School of Medicine, Atlanta, GA, United States

Synopsis

Convergent clinical and neuroimaging evidence suggests that cognitive-affective and vestibular symptoms are interrelated: affective disorders not only co-occur with vestibular dysfunction but may also influence vestibular processing. However, the topology of the vestibular/cognitive/affective network (‘vestibular neuromatrix’) is not well-defined. The present study leveraged graph theory metrics to assess the functional and structural connectivity among 82 regions of interest in healthy controls and in patients with subacute post-concussive vestibular dysfunction. Patients exhibited deficiencies in connectivity among vestibular, pre- and orbitofrontal, and visual regions, as well as in the integration of visual and vestibular information, visuospatial attention, and monitoring of internal state.

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