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Abstract #2563

The vestibular neuromatrix in patients with post-concussive vestibular dysfunction and healthy controls

Jeremy Lee Smith1, Anna Trofimova1, Vishwadeep Ahluwalia2,3, Jose J. Casado Garrido4, Julia Hurtado5, Rachael Frank5, April Hodge5, Russell K. Gore4,5, and Jason W. Allen1,4,6
1Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Georgia State University, Atlanta, GA, United States, 3Center for Advanced Brain Imaging, Georgia Institute of Technology, Atlanta, GA, United States, 4Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, 5Shepherd Center, Atlanta, GA, United States, 6Neurology, Emory University School of Medicine, Atlanta, GA, United States


Convergent clinical and neuroimaging evidence suggests that cognitive-affective and vestibular symptoms are interrelated: affective disorders not only co-occur with vestibular dysfunction but may also influence vestibular processing. However, the topology of the vestibular/cognitive/affective network (‘vestibular neuromatrix’) is not well-defined. The present study leveraged graph theory metrics to assess the functional and structural connectivity among 82 regions of interest in healthy controls and in patients with subacute post-concussive vestibular dysfunction. Patients exhibited deficiencies in connectivity among vestibular, pre- and orbitofrontal, and visual regions, as well as in the integration of visual and vestibular information, visuospatial attention, and monitoring of internal state.

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