Brain tumors lead to modifications of brain networks known as functional reorganization or plasticity, which may be compensatory in nature and lead to valuable clinical applications. However, the determinants of plasticity are unclear. We evaluated functional networks of 30 low-grade (LGG) and 30 high-grade (HGG) left-hemispheric gliomas versus 20 healthy controls (HC) through rs-fMRI and graph-theory. We hypothesized that tumor grade and location impact brain connectivity. Our results show that both LGG and HGG develop ipsilateral and contralateral functional network changes. Additionally, tumor location is crucial: frontal and temporal tumors show bilateral modifications; parietal and insular tumors only local effects.
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