Resting-state fMRI studies performed during natural sleep indicate that functional-connectivity in ASD-children begins to differentially mature from earliest periods of life and continues to have distinct patterns throughout early development. In current study, we have performed rs-fMRI in younger (12 to 36-months-of-age) cohorts of ASD, ASD-siblings, and typically developing children to look for functional-connectivity patterns. We observed significantly reduced functional-connectivity in language, social-cognition, and motor regions than controls and ASD-siblings. Interestingly, some of these regions are also considerably different when compared between ASD and ASD-siblings. Altered connectivity may use for targeted interventional therapy for better clinical outcomes in ASD-children.
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