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Abstract #2565

Emerging functional connectivity differences in children with autism spectrum disorders and younger siblings affected with Autism

Manoj Kumar1, Sachin Patalasingh1, Chandrakanta Hiremath1, Jitender Saini1, K. John VijaySagar2, BK Yamini3, and Rose Dawn Bhrath1
1Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India, 2Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India, 3Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences, Bangalore, India


Resting-state fMRI studies performed during natural sleep indicate that functional-connectivity in ASD-children begins to differentially mature from earliest periods of life and continues to have distinct patterns throughout early development. In current study, we have performed rs-fMRI in younger (12 to 36-months-of-age) cohorts of ASD, ASD-siblings, and typically developing children to look for functional-connectivity patterns. We observed significantly reduced functional-connectivity in language, social-cognition, and motor regions than controls and ASD-siblings. Interestingly, some of these regions are also considerably different when compared between ASD and ASD-siblings. Altered connectivity may use for targeted interventional therapy for better clinical outcomes in ASD-children.

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