Abstract #2566

Altered dynamic functional network connectivity in post-stroke dementia with subcortical lesion

Qianwen Wu^1,2, Huaying Cai³, Linhui Ni³, Guocan Han⁴, Zhiyong Zhao¹, and Dan Wu¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Engineering, University of Oxford, Oxford, United Kingdom, ³Department of Neurology, Neuroscience Center,, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China, ⁴Department of Radiology, Neuroscience Center,, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

Synopsis

This study aimed to explore the changes of functional network connectivity (FNC) in post-stroke dementia (PSD) using a dynamic FNC (dFNC) method. We collected resting-state fMRI data from16 PSD patients, 20 post-stroke non-dementia (PSND) patients and 19 normal controls, and identified 13 functional networks. We found PSD-specific decreases in the dFNC between default mode network and executive control network as well as visual network, which were not observed in static FNC analysis. Moreover, PSD showed a significant decrease in time-variance of global efficiency in whole brain compared with PSND. These changes were associated with the clinical assessments of patients.

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