Altered dynamic functional network connectivity in post-stroke dementia with subcortical lesion
Qianwen Wu1,2, Huaying Cai3, Linhui Ni3, Guocan Han4, Zhiyong Zhao1, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Engineering, University of Oxford, Oxford, United Kingdom, 3Department of Neurology, Neuroscience Center,, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China, 4Department of Radiology, Neuroscience Center,, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
This study aimed to explore the changes of functional network connectivity (FNC) in post-stroke dementia (PSD) using a dynamic FNC (dFNC) method. We collected resting-state fMRI data from16 PSD patients, 20 post-stroke non-dementia (PSND) patients and 19 normal controls, and identified 13 functional networks. We found PSD-specific decreases in the dFNC between default mode network and executive control network as well as visual network, which were not observed in static FNC analysis. Moreover, PSD showed a significant decrease in time-variance of global efficiency in whole brain compared with PSND. These changes were associated with the clinical assessments of patients.
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