Abstract #2583

Tumor stiffness based on 3D MR Elastography as a marker for predicting the aggressiveness in cervical cancer

Yuanqiang Xiao¹, Wenying Chen¹, Mengsi Li¹, Jun Chen², Meng Yin², Richard L. Ehman², and Jin Wang¹

¹Department of Radiology, The third affiliated hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, United States

Synopsis

Preoperative prediction of aggressiveness (histologic subtype, grade of differentiation, Federation International of Gynecology and Obstetrics (FIGO) stage) in cervical cancer (CC) using a noninvasive method remains a challenge. 3D MR Elastography (MRE) is a novel functional MRI technique which can quantitatively characterize the mechanical properties of tumors. We retrospectively analyzed 24 CC patients undergoing 3D MRE examinations and found that tumor stiffness (TS) in adenocarcinoma and FIGO stage III/IV was significantly higher than that in squamous cell carcinoma and FIGO stage I/II. TS based on 3D MRE could serve as a potential noninvasive marker to assess the aggressiveness in CC.

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