Abstract #2584

Quantifying and mapping hypoxia modification in patients with uterine cervical cancer using oxygen-enhanced MRI

Anubhav Datta^1,2, Michael Dubec^1,3, David Buckley^3,4, Damien McHugh³, Amal Salah⁵, Ross Little¹, Michael Berks¹, Susan Cheung¹, Catharine West¹, Ananya Choudhury^1,6, Lisa Barraclough⁶, Peter Hoskin^1,6,7, and James P. B. O'Connor^1,2,8

¹Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, ²Clinical Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom, ³Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁴School of Medicine, University of Leeds, Leeds, United Kingdom, ⁵Proton Beam Therapy Dept, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁶Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁷Mount Vernon Cancer Centre, Northwood, United Kingdom, ⁸Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom

Synopsis

Hypoxia is a ubiquitous negative prognostic factor in solid tumours. Oxygen-enhanced MRI can spatially map regions refractory to an oxygen challenge and, when combined with a perfusion measurement, has the potential to quantify hypoxia in vivo. We developed the technique in healthy volunteers before successfully translating into a longitudinal patient study of patients with cervical carcinoma. We present initial data to support OE-MRI quantifying and mapping hypoxia modification following therapy in this clinical dataset.

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