OE-MRI is an emerging technique for identifying, mapping and quantifying tumour hypoxia. Current analysis is based on combining data with a perfusion map and categorising each voxel absolutely as hypoxic, normoxic or necrotic. In this study we use bootstrap analysis to map the uncertainty on the biomarker pOxy-R. We investigate how this performs in synthetic tumour data before applying the method to data from 9 patients with rectal cancer undergoing chemoradiotherapy. Bootstrapping enabled estimates of confidence intervals for change, thus identifying those patients who exhibited hypoxia modification on therapy.
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