Abstract #2722

Analysis of variability of diffusion tensor imaging measurements using co-electrospun fibre phantom

Fenglei Zhou^1,2, Fei Gao³, Longji Xu³, Jing Yang³, Fuxin Ren³, Weibo Chen⁴, and Geoff JM Parker^1,5

¹Centre for Medical Image Computing, University College London, London, United Kingdom, ²School of Pharmacy, University College London, London, United Kingdom, ³Department of Radiology,Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, ⁴Philips Heathcare, Shanghai, China, ⁵Bioxydyn Limited, Manchester, United Kingdom

Synopsis

Brain diffusion tensor imaging (DTI) measurements are sensitive to pathological changes, but in order for them to be of greatest use it is vital to understand intra-scanner and inter-scanner variations in DTI metrics. Here we demonstrate a physical phantom with variable pore sizes and fibre orientation that can be used to assess the repeatability and reproducibility of DTI measurements across scanners and protocols and present its application in assessing 9 separate scanner/protocol combinations.

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