Analysis of variability of diffusion tensor imaging measurements using co-electrospun fibre phantom
Fenglei Zhou1,2, Fei Gao3, Longji Xu3, Jing Yang3, Fuxin Ren3, Weibo Chen4, and Geoff JM Parker1,5
1Centre for Medical Image Computing, University College London, London, United Kingdom, 2School of Pharmacy, University College London, London, United Kingdom, 3Department of Radiology,Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, 4Philips Heathcare, Shanghai, China, 5Bioxydyn Limited, Manchester, United Kingdom
Brain diffusion tensor imaging (DTI) measurements are sensitive to pathological changes, but in order for them to be of greatest use it is vital to understand intra-scanner and inter-scanner variations in DTI metrics. Here we demonstrate a physical phantom with variable pore sizes and fibre orientation that can be used to assess the repeatability and reproducibility of DTI measurements across scanners and protocols and present its application in assessing 9 separate scanner/protocol combinations.
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