Abstract #2723

Microscopically Anisotropic and Randomly Oriented 3D Printed MRI Phantom for Size, Orientation, and Anisotropy Validation in Diffusion Imaging

Velencia Witherspoon¹, Michal Komlosh^1,2,3, Dan Benjamini^1,2,3, Peter Basser^1,3, and Nick Lavrik⁴

¹Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ³The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, United States, ⁴The Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National Laboratory (ORNL), Oakridge, TN, United States

Synopsis

Microscopically anisotropic but globally isotropic DTI MRI phantom was designed and fabricated using a 2 Photon Nanoscribe 3D Printer. The capillary array blocks were measured aligned and randomly oriented to determine the ability of ddPFG and DTI to characterize local anisotropy in a globally isotropic system. These experiments combined computational methods can provide MRI phantoms that can be employed to validate novel or proposed microstructure imaging experiments.

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