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Abstract #2724

Investigation of sodium alginate- and polyvinyl alcohol-based anisotropic hydrogel phantoms for calibration applications by DWI at 0.6 T

Weronika Mazur1,2, Anna Stefańska-Bernatowicz2, Ewa Stodolak-Zych3, and Artur Tadeusz Krzyżak2
1Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Kraków, Poland, 2Faculty of Geology, Geophysics and Environmental Protection, AGH University of Science and Technology, Kraków, Poland, 3Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Kraków, Poland


Anisotropic hydrogels has been attracting attention for biomedical purposes. These highly-hydrated materials have potential for tissue-mimicking and then, may serve for advanced medical imaging studies. In the work, we present two types of anisotropic hydrogels made from sodium alginate (NA) and polyvinyl alcohol (PVA) in the form of fiber bundle- a single component for larger phantom. We investigated their potential for diffusion-weighted imaging. NA-based phantoms are characterized by highly uniform diffusivity distribution, even higher then water. Single component turned out to be insufficient for the accurate quantification of the microstructure. PVA-based phantom exhibited desirable diffusion properties for tissue-mimicking.

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