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Abstract #2829

Feasibility of T1-weighted USPIO-enhanced MR imaging of pelvic lymph nodes using stack-of-spirals UTE

Marnix C. Maas1, Patrik Zámecnik1, Moritz J. Schneider2,3, Thomas Gaass2,4, Thomas Benkert5, Julien Dinkel2,4, and Tom W.J. Scheenen1
1Medical Imaging, Radboudumc, Nijmegen, Netherlands, 2Comprehensive Pneumology Center, German Center for Lung Research (DZL), Munich, Germany, 3Antaros Medical AB, Mölndal, Sweden, 4Department of Radiology, University Hospital, LMU Munich, Munich, Germany, 5MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany


Detection of lymph node (LN) metastases can be improved using Ferumoxtran-10, an ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agent . Commonly, T2* contrast is used to distinguish between normal LNs (high USPIO uptake, low signal) and metastases (low uptake, high signal). T1-weighted imaging may offer complementary information, but is challenging because of the strong T2* effects of the contrast agent. This work investigates whether ultrashort echotime (UTE) imaging with a stack-of-spirals sequence can mitigate this issue. High-resolution USPIO-enhanced T1-weighted UTE of the pelvis was achieved, and T1-mediated signal hyperintensities were indeed observed in LNs in patients with prostate cancer.

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