Detection of lymph node (LN) metastases can be improved using Ferumoxtran-10, an ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agent . Commonly, T2* contrast is used to distinguish between normal LNs (high USPIO uptake, low signal) and metastases (low uptake, high signal). T1-weighted imaging may offer complementary information, but is challenging because of the strong T2* effects of the contrast agent. This work investigates whether ultrashort echotime (UTE) imaging with a stack-of-spirals sequence can mitigate this issue. High-resolution USPIO-enhanced T1-weighted UTE of the pelvis was achieved, and T1-mediated signal hyperintensities were indeed observed in LNs in patients with prostate cancer.
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