Abstract #2879

Myelin Alterations during the Development of an Absence Seizure Mouse Model

Gustavo Chau Loo Kung¹, Juliet Knowles², Lijun Ni², John Huguenard², Michelle Monje², and Jennifer McNab³

¹Bioengineering Department, Stanford University, Stanford, CA, United States, ²Neurology Department, Stanford University, Stanford, CA, United States, ³Radiology Department, Stanford University, Stanford, CA, United States

Synopsis

Maladaptive myelination may be related to the increasing frequency of absence seizures. To explore this connection, we performed MRI microstructural measurements in ex vivo mouse brains from the Scn8amed+/- model of absence epilepsy in two cohorts of mice at two points of their development, both before and after seizures were well established. Our MRI g-ratio results strongly agree with our previous findings based on electron microscopy and show a clear alteration of myelination throughout the anterior portion of the corpus callosum.

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