Meeting Banner
Abstract #2880

Early MRI biomarkers in amyotrophic lateral sclerosis (ALS): DTI and functional connectivity.

Juan Carlos Quizhpilema1, Pablo Lecumberri2, Marta Vidorreta3, Tamara Laxe4, Mikel San Miguel5, Javier Díaz6, Inmaculada Pagola5, Marisol Gómez1, Ivonne Jericó5, and Teresa Cabada4
1Department of Statistics, Computer Science and Mathematics, UPNA, Pamplona, Spain, 2Movalsys, Pamplona, Spain, 3Siemens Healthineers, Madrid, Spain, 4Radiology department, HUN, Pamplona, Spain, 5Neurology department, HUN, Pamplona, Spain, 6Psychiatry department, HUN, Pamplona, Spain


Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by damage to motor neurons. The search for early biomarkers is relevant due to their rapid progression.This study aims to analyze structural and functional measures in a group of newly diagnosed ALS patients, compare them with a group of healthy controls, and evaluate changes longitudinally at a 6-month follow-up.Twenty patients and 15 controls were recruited. The MRI examination included a T1-weighted scan, DTI, rs-fMRI. ALS shows involvement in motor and non-motor areas as shown by DTI in cortical activity in the early phase and in time progression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here