Abstract #2880

Early MRI biomarkers in amyotrophic lateral sclerosis (ALS): DTI and functional connectivity.

Juan Carlos Quizhpilema¹, Pablo Lecumberri², Marta Vidorreta³, Tamara Laxe⁴, Mikel San Miguel⁵, Javier Díaz⁶, Inmaculada Pagola⁵, Marisol Gómez¹, Ivonne Jericó⁵, and Teresa Cabada⁴

¹Department of Statistics, Computer Science and Mathematics, UPNA, Pamplona, Spain, ²Movalsys, Pamplona, Spain, ³Siemens Healthineers, Madrid, Spain, ⁴Radiology department, HUN, Pamplona, Spain, ⁵Neurology department, HUN, Pamplona, Spain, ⁶Psychiatry department, HUN, Pamplona, Spain

Synopsis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by damage to motor neurons. The search for early biomarkers is relevant due to their rapid progression.This study aims to analyze structural and functional measures in a group of newly diagnosed ALS patients, compare them with a group of healthy controls, and evaluate changes longitudinally at a 6-month follow-up.Twenty patients and 15 controls were recruited. The MRI examination included a T1-weighted scan, DTI, rs-fMRI. ALS shows involvement in motor and non-motor areas as shown by DTI in cortical activity in the early phase and in time progression.

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