Myelin water imaging (MWI) and diffusion tensor imaging (DTI) was performed at two longitudinal time points, approximately two years apart, during chemotherapy in patients treated for acute lymphoblastic leukemia (ALL). DTI metrics correlated with MWF and LWF at time point 1, but the correlations were weaker at time point 2 (TP2). This may be caused by a possible decoupling of the relationship at TP2 as the brain is recovering from the impact of chemotherapy.
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