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Abstract #2883

Comprehensive brainstem imaging using MT, QSM and DTI for atypical parkinsonism diagnosis

Samy Abo Seada1, Anke W. van der Eerden1, Agnita Boon2, and Juan A. Hernandez-Tamames1,3
1Department of Radiology and Nuclear medicine, Erasmus MC, Rotterdam, Netherlands, 2Department of Neurology, Erasmus MC, Rotterdam, Netherlands, 3Department of Imaging Physics, TU Delft, Delft, Netherlands


Differentiating atypical parkinsonism (AP) from idiopathic Parkinson’s disease (PD) remains a challenge in clinical practice. Based on a recent review on differentiating atypical parkinsonisms using MRI, we developed a dedicated MRI protocol including magnetization transfer (MT), quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI) for improving diagnosis. Using pilot data from a healthy volunteer, we show how the assessment of important structures (substantia nigra and locus coeruleus) can be improved using a comprehensive combination of MRI techniques.

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