Differentiating atypical parkinsonism (AP) from idiopathic Parkinson’s disease (PD) remains a challenge in clinical practice. Based on a recent review on differentiating atypical parkinsonisms using MRI, we developed a dedicated MRI protocol including magnetization transfer (MT), quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI) for improving diagnosis. Using pilot data from a healthy volunteer, we show how the assessment of important structures (substantia nigra and locus coeruleus) can be improved using a comprehensive combination of MRI techniques.
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