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Abstract #2923

Oxygen induced T1 changes in head and neck anatomical structures

Alastair McCabe1,2, Damian Borys3, Judith Christian1, Solange Pereira4, Selene Rowe4, Paul S Morgan5, Jagrit Shah4, Elaine Blackshaw6, Stewart Martin7, and Rafal Panek2,6
1Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 2School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3Department of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland, 4Department of Radiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 5Radiological Sciences, University of Nottingham, Nottingham, United Kingdom, 6Department of Medical Physics & Clinical Engineering, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 7University of Nottingham Biodiscovery Institute, Nottingham, United Kingdom

Synopsis

Oxygen enhanced MRI (OE-MRI) is a proposed tumour hypoxia imaging technique that is yet to be widely applied in the head and neck. 7 participants, 3 with suspected head and neck squamous cell carcinoma (HNSCC) were scanned using 3D spoiled GRE-DIXON. After on air scans, oxygen was delivered via a non-rebreather mask. T1 times were determined on in-phase images. Oxygenation led to statistically significant T1 shortening in CSF, thyroid and neck nodes. OE-MRI shows promise in identifying hypoxic regions in the head and neck. Further work investigating the feasibility of OE-MRI to detect hypoxic regions in HNSCC is warranted.

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