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Abstract #2924

OptiPulse: a flexible optimization framework for short water-selective radiofrequency pulse design

Xavier Sieber1,2, Jessica A. M. Bastiaansen1,2,3,4, Christopher W. Roy1,2, Jonas Richiardi1,2, Matthias Stuber1,2, and Ruud B. van Heeswijk1,2
1Department of Medical Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 2University of Lausanne (UNIL), Lausanne, Switzerland, 3Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 4Translational Imaging Center, Sitem-insel, Bern, Switzerland


We present a flexible optimization framework to design spectral-selective radiofrequency pulses using numerical optimization on Bloch equation simulation. The RF pulse performance is assessed using a composite loss function for both fat suppression and power requirement. The framework was used to design three binomial (1-1, 1-2-1 and 1-3-3-1) and one cubic B-splines interpolated RF pulses. These pulses were then tested in vitro as well as in vivo in the knee and in the heart, where they demonstrated robust fat suppression comparable to a state-of-the-art water-selective pulse.

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