Abstract #2949

Effect of Dobutamine Stress on Ocular Blood Flow Measurements Using 3D Pseudocontinuous Arterial Spin Labeling

linkun cai¹, haijun niu¹, pengling ren², yawen liu¹, tingting zhang², jing li², hao wang², wei zheng³, hongxia yin², and zhenchang wang¹

¹Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China, ²Beijing Friendship Hospital, Beijing, China, ³Chinese Academy of Sciences, Beijing, China

Synopsis

Dobutamine stress testing is a very widely used tool in cardiological investigation. However, little is known about the effect of dobutamine on adult ocular blood flow with clinical dosage. In this study, we infused dobutamine in human subjects and examined the effects of dobutamine on ocular blood flow using 3D pseudocontinuous arterial spin labeling(3D-pcASL). Dobutamine infusion significantly increased the ocular blood flow. And the heart rate and diastolic blood pressure were the main factors affecting the ocular blood flow.

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