Effect of Dobutamine Stress on Ocular Blood Flow Measurements Using 3D Pseudocontinuous Arterial Spin Labeling
linkun cai1, haijun niu1, pengling ren2, yawen liu1, tingting zhang2, jing li2, hao wang2, wei zheng3, hongxia yin2, and zhenchang wang1
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China, 2Beijing Friendship Hospital, Beijing, China, 3Chinese Academy of Sciences, Beijing, China
Dobutamine stress testing is a very widely used tool in cardiological investigation. However, little is known about the effect of dobutamine on adult ocular blood flow with clinical dosage. In this study, we infused dobutamine in human subjects and examined the effects of dobutamine on ocular blood flow using 3D pseudocontinuous arterial spin labeling(3D-pcASL). Dobutamine infusion significantly increased the ocular blood flow. And the heart rate and diastolic blood pressure were the main factors affecting the ocular blood flow.
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