Parkinson’s disease state modulates the effect of nigral iron deposition on the large-scale brain networks.
Jiaqi Wen1, Xiaojun Guan1, Tao Guo1, Jingjing Wu1, Xueqin Bai1, Cheng Zhou1, Haoting Wu1, Xiaocao Liu1, Jingwen Chen1, Zhengye Cao1, Yong Zhang2, Luyan Gu3, Jiali Pu3, Baorong Zhang3, Minming Zhang1, and Xiaojun Xu1
1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2GE Healthcare, Shanghai, China, Shanghai, China, 3Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
In Parkinson’s disease (PD), nigral iron deposition exacerbates a-synuclein aggregation. In our study, we divided PD and normal controls (NC) into high iron group and normal iron group according to the median of nigral magnetic susceptibility of NC, respectively. ICA method was applied to separate brain large-scale networks. The PD*iron interaction effect on brain functional networks were investigated by mixed effect analysis. We found that PD disease status specifically moderates the effect of nigral iron deposition on the function of some regions in BGN and VN, which partially mediates the relationship between nigral iron deposition and disease severity.
This abstract and the presentation materials are available to members only;
a login is required.