In Parkinson’s disease (PD), nigral iron deposition exacerbates a-synuclein aggregation. In our study, we divided PD and normal controls (NC) into high iron group and normal iron group according to the median of nigral magnetic susceptibility of NC, respectively. ICA method was applied to separate brain large-scale networks. The PD*iron interaction effect on brain functional networks were investigated by mixed effect analysis. We found that PD disease status specifically moderates the effect of nigral iron deposition on the function of some regions in BGN and VN, which partially mediates the relationship between nigral iron deposition and disease severity.
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