Abstract #2960

Parkinson’s disease state modulates the effect of nigral iron deposition on the large-scale brain networks.

Jiaqi Wen¹, Xiaojun Guan¹, Tao Guo¹, Jingjing Wu¹, Xueqin Bai¹, Cheng Zhou¹, Haoting Wu¹, Xiaocao Liu¹, Jingwen Chen¹, Zhengye Cao¹, Yong Zhang², Luyan Gu³, Jiali Pu³, Baorong Zhang³, Minming Zhang¹, and Xiaojun Xu¹

¹Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²GE Healthcare, Shanghai, China, Shanghai, China, ³Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

In Parkinson’s disease (PD), nigral iron deposition exacerbates a-synuclein aggregation. In our study, we divided PD and normal controls (NC) into high iron group and normal iron group according to the median of nigral magnetic susceptibility of NC, respectively. ICA method was applied to separate brain large-scale networks. The PD*iron interaction effect on brain functional networks were investigated by mixed effect analysis. We found that PD disease status specifically moderates the effect of nigral iron deposition on the function of some regions in BGN and VN, which partially mediates the relationship between nigral iron deposition and disease severity.

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