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Abstract #2985

Improving laminar functional specificity and sensitivity using combined spin- and gradient-echo EPI at 7 T

SoHyun Han1,2, Seulgi Eun1,2, HyungJoon Cho3, Kâmil Uludaǧ1,2, and Seong-Gi Kim1,2
1Center for Neuroscience Imaging Research, Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of


Both spatial specificity and sensitivity are important for high spatial resolution fMRI. In this study, we applied a filter designed based on the ΔR2*/ΔR2 ratio to enhance both the sensitivity and specificity of the BOLD signal using SAGE-EPI sequence. fMRI experiments during fist-clenching with touching with 0.8 mm isotropic resolution were performed and we directly compared the layer profile of SAGE-BOLD with that of GE- and SE-BOLD in the primary sensory and motor cortices. Vessel-size tuned SAGE-BOLD fMRI provided enhanced laminar specificity and sensitivity in the gray matter region.

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