Abstract #2985

Improving laminar functional specificity and sensitivity using combined spin- and gradient-echo EPI at 7 T

SoHyun Han^1,2, Seulgi Eun^1,2, HyungJoon Cho³, Kâmil Uludaǧ^1,2, and Seong-Gi Kim^1,2

¹Center for Neuroscience Imaging Research, Suwon, Korea, Republic of, ²Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ³Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of

Synopsis

Both spatial specificity and sensitivity are important for high spatial resolution fMRI. In this study, we applied a filter designed based on the ΔR₂^*/ΔR₂ ratio to enhance both the sensitivity and specificity of the BOLD signal using SAGE-EPI sequence. fMRI experiments during fist-clenching with touching with 0.8 mm isotropic resolution were performed and we directly compared the layer profile of SAGE-BOLD with that of GE- and SE-BOLD in the primary sensory and motor cortices. Vessel-size tuned SAGE-BOLD fMRI provided enhanced laminar specificity and sensitivity in the gray matter region.

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