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Abstract #2986

Laminar BOLD normalization using breath-hold challenge

Seulgi Eun1,2,3, SoHyun Han1,2, Kâmil Uludaǧ1,2,4, and Seong-Gi Kim1,2
1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Biomedical Engineering, Kyung Hee University, Yongin, Korea, Republic of, 4Techna Institute & Koerner Scientist in MR Imaging, University Health Network, Toronto, ON, Canada


Limitations of the several developed laminar fMRI acquisition methods and pial and intra-cortical ascending vein contamination of the gradient-echo (GE) restrict the neural specificity of the depth profiles. Preserving the advantage of high sensitivity of the GE-EPI sequence, we propose a simple and intuitive model to normalize laminar BOLD with breath holding. Our normalization method increased specificity of the BOLD activation map and emphasized laminar BOLD signal changes in gray matter regions by suppressing signal changes from CSF. This approach takes into account the different vascular sensitivity across layers but may not fully account for the draining vein contamination.

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