We investigated the stability of brain functional architectures and its relationship with cognitive impairment in cirrhotic patients. From healthy controls, to NHE, and to minimal hepatic encephalopathy(MHE) group, a stepwise reduction of FS was found in right supramarginal gyrus , right middle cingulate cortex, left superior frontal gyrus, and BPCC; whereas, a progressive increment of FS was observed in left middle occipital gyrus and right temporal pole. Mean FS was correlated with Psychometric Hepatic Encephalopathy Score among cirrhotic patients. FS index showed moderate discrimination potential between NHE and MHE. FS alteration could be potential biomarkers serving for diagnosis about MHE.