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Abstract #3034

Altered macroscale neurovascular coupling in vascular cognitive impairment

Zhao Ruan1 and Weiyin Vivian Liu2
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China, 2GE Healthcare, Beijing, China


This study aims to integrate psychological behavior, clinical biochemistry and other indicators, and use multi-mode MRI technology to explore specific imaging indicators of VCIND neurovascular coupling (NVC). NVC analysis and CBF/ ALFF ratio calculation were performed to investigate the neurovascular coupling changes and clinical significance of LVCI, SVCI and HC. Regardless of the level of the whole brain or brain regions, we have found neurovascular uncoupling in VCIND patients compared with healthy controls. These findings will be helpful in screening patients with VCIND, and has important theoretical and clinical significance in preventing and delaying the development of dementia.

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