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Abstract #3035

Stressful life events associate with adolescent depression through dysfunction of frontoparietal network

Yingxue Gao1, Ruohan Feng2, Lihua Zhuo2, Kaili Liang1, Weijie Bao1, Hui Qiu1, Zilin Zhou1, Guoping Huang3, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China, Mianyang, China, 3Department of Psychiatry, the Third Hospital of Mianyang, Sichuan Mental Health Center, China, Mianyang, China


The current study investigate functional network alterations in adolescent MDD using the clustering analysis. We found that adolescents with MDD showed decreased connectivity between the frontoparietal network (FPN) and other networks relative to HC. The global connectivity strength of FPN was negatively correlated with the punishment and academic pressure factors, and mediated the association between these two stressors and depression. Our findings suggest that punishment and academic pressure may contribute to the development of depression in adolescence through dysfunction of the FPN, which may promote future prevention of adolescent MDD.

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