Abstract #3035

Stressful life events associate with adolescent depression through dysfunction of frontoparietal network

Yingxue Gao¹, Ruohan Feng², Lihua Zhuo², Kaili Liang¹, Weijie Bao¹, Hui Qiu¹, Zilin Zhou¹, Guoping Huang³, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China, Mianyang, China, ³Department of Psychiatry, the Third Hospital of Mianyang, Sichuan Mental Health Center, China, Mianyang, China

Synopsis

The current study investigate functional network alterations in adolescent MDD using the clustering analysis. We found that adolescents with MDD showed decreased connectivity between the frontoparietal network (FPN) and other networks relative to HC. The global connectivity strength of FPN was negatively correlated with the punishment and academic pressure factors, and mediated the association between these two stressors and depression. Our findings suggest that punishment and academic pressure may contribute to the development of depression in adolescence through dysfunction of the FPN, which may promote future prevention of adolescent MDD.

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