Signal from conventional single-echo fMRI depends on multiple factors including cerebral metabolic rate for oxygen (CMRO2), blood flow (CBF) and blood volume (CBV). Interpretation of functional connectivity analyses derived from conventional single-echo fMRI is complicated due to coupling of various factors in the fMRI signal. In this work, we use multi-echo task-fMRI to estimate functional connectivity from fluctuations in R2* (transverse relaxation rate) assumed to be surrogates for fluctuations in CMRO2. We also investigate the similarities and differences between single-echo and R2* multi-echo fMRI derived functional activation in a visuo-motor decision task paradigm.
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