Abstract #3037

Improved reliability of functional connectivity with multi-echo task fMRI

Amod S Jog¹, Radhika Madhavan², Nastaren Abad³, Eric Fiveland³, Brice Fernandez⁴, Chitresh Bhushan³, Luca Marinelli³, H Doug Morris⁵, and Thomas K Foo³

¹GE Global Research, Bangalore, India, ²GE Healthcare, Niskayuna, NY, United States, ³GE Global Research, Niskayuna, NY, United States, ⁴GE Healthcare, Buc, France, ⁵Walter Reed National Military Medical Center, Bethesda, MD, United States

Synopsis

Signal from conventional single-echo fMRI depends on multiple factors including cerebral metabolic rate for oxygen (CMRO₂), blood flow (CBF) and blood volume (CBV). Interpretation of functional connectivity analyses derived from conventional single-echo fMRI is complicated due to coupling of various factors in the fMRI signal. In this work, we use multi-echo task-fMRI to estimate functional connectivity from fluctuations in R2* (transverse relaxation rate) assumed to be surrogates for fluctuations in CMRO₂. We also investigate the similarities and differences between single-echo and R2* multi-echo fMRI derived functional activation in a visuo-motor decision task paradigm.

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