Improved reliability of functional connectivity with multi-echo task fMRI
Amod S Jog1, Radhika Madhavan2, Nastaren Abad3, Eric Fiveland3, Brice Fernandez4, Chitresh Bhushan3, Luca Marinelli3, H Doug Morris5, and Thomas K Foo3
1GE Global Research, Bangalore, India, 2GE Healthcare, Niskayuna, NY, United States, 3GE Global Research, Niskayuna, NY, United States, 4GE Healthcare, Buc, France, 5Walter Reed National Military Medical Center, Bethesda, MD, United States
Signal from conventional single-echo fMRI depends on multiple factors including cerebral metabolic rate for oxygen (CMRO2), blood flow (CBF) and blood volume (CBV). Interpretation of functional connectivity analyses derived from conventional single-echo fMRI is complicated due to coupling of various factors in the fMRI signal. In this work, we use multi-echo task-fMRI to estimate functional connectivity from fluctuations in R2* (transverse relaxation rate) assumed to be surrogates for fluctuations in CMRO2. We also investigate the similarities and differences between single-echo and R2* multi-echo fMRI derived functional activation in a visuo-motor decision task paradigm.
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