Abstract #3083

3D texture analysis of MRI relaxation time maps for assessment of repair cartilage with treatment of mesenchymal progenitor cells

Xinxin Zhao¹, Jingjing Ruan¹, Jia Li², Chengxiang Dai³, and Yan Zhou¹

¹Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China., Shanghai, China, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China., Shanghai, China, ³Cellular Biomedicine Group, Inc., No. 85 Faladi Road, Building 3, Zhangjiang, Pudong New Area, Shanghai, 201210, China., Shanghai, China

Synopsis

We used 3D texture analysis of MRI relaxation times, combined with clinical outcomes, to evaluate the potential of repair cartilage with allogeneic human adipose-derived mesenchymal progenitor cells in patients with KOA. Significant differences were observed in texture RLM parameters of T1rho and T2 maps in patients. We also found correlations between WOMAC pain scores and texture parameters, suggesting the spatial heterogeneity of relaxation time maps maybe associated with clinical scores. As conclusion, texture analysis has potential applications in understanding mechanism of stem cells repairing cartilage and assessing response to treatment.

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