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Abstract #3293

Phenotypic associations of magnetic susceptibility in the brain

Chaoyue Wang1, Stephen M. Smith1, Fidel Alfaro-Almagro1, Gwenaëlle Douaud1, Johannes C. Klein1,2, Alberto Llera3, Aurea B. Martins-Bach1, Cristiana Fiscone4,5, Richard Bowtell4, Lloyd T. Elliott6, Benjamin C. Tendler1, and Karla L. Miller1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, United Kingdom, 3Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 4Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 5Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 6Department of Statistics and Actuarial Science, Simon Fraser University, Vancouver, BC, Canada


In this abstract, we describe our findings from the phenotypic association analyses (univariate Pearson correlations) between 17,485 non-imaging phenotypes and QSM (and T2*) measures using data from 35,885 subjects in UK Biobank. In total, we identify statistically-significant associations of 251 phenotypes with QSM IDPs. Here we describe example associations in blood assays, health outcomes, food and drink, and alcohol consumption categories in detail. Our results demonstrate that QSM and T2* contribute complementary information. This new QSM resource provides an opportunity to investigate susceptibility contrast in previously unexplored territory, which might lead to advances in application of QSM in neuroscience.

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