Abstract #3293

Phenotypic associations of magnetic susceptibility in the brain

Chaoyue Wang¹, Stephen M. Smith¹, Fidel Alfaro-Almagro¹, Gwenaëlle Douaud¹, Johannes C. Klein^1,2, Alberto Llera³, Aurea B. Martins-Bach¹, Cristiana Fiscone^4,5, Richard Bowtell⁴, Lloyd T. Elliott⁶, Benjamin C. Tendler¹, and Karla L. Miller¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, United Kingdom, ³Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ⁴Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁵Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, ⁶Department of Statistics and Actuarial Science, Simon Fraser University, Vancouver, BC, Canada

Synopsis

In this abstract, we describe our findings from the phenotypic association analyses (univariate Pearson correlations) between 17,485 non-imaging phenotypes and QSM (and T2*) measures using data from 35,885 subjects in UK Biobank. In total, we identify statistically-significant associations of 251 phenotypes with QSM IDPs. Here we describe example associations in blood assays, health outcomes, food and drink, and alcohol consumption categories in detail. Our results demonstrate that QSM and T2* contribute complementary information. This new QSM resource provides an opportunity to investigate susceptibility contrast in previously unexplored territory, which might lead to advances in application of QSM in neuroscience.

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