Meeting Banner
Abstract #3294

Cumulant expansion with localization

Maryam Afzali1,2, Tomasz Pieciak3, Derek K Jones2, Jürgen Schneider4,5, and Evren Özarslan6,7
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3LPI, ETSI Telecomunicación, Universidad de Valladolid, Valladolid, Spain, 4Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom, 5Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 6Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 7Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden

Synopsis

Diffusion MR is sensitive to the microstructural features of a sample. Fine-scale characteristics can be probed by employing strong diffusion gradients while the small gradient regime is determined by the cumulants of the distribution of particle displacements. However, the cumulant expansion suffers from a finite convergence radius and cannot represent the ‘localization regime’ that emerges at higher gradient strengths characterized by a stretched exponential dependence. Here, we propose a new representation for the diffusion MR signal. Our method provides not only a robust estimate of the first few cumulants but also a meaningful extrapolation of the signal decay.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords