NORDIC PCA increases tSNR in both human and mouse resting-state fMRI for potential improvements in cerebrovascular reactivity mapping
Emily L. Tse1, Russell W. Chan1,2, Sarah Y. Wu1, Yixi Xue1, Peiying Liu3, Steen Moeller4, and Kevin C. Chan1,5
1Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States, 2Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States, 3Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 4Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States, 5Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States
Cerebrovascular reactivity (CVR) reflects the response of cerebral blood vessels to vasoactive stimuli. Whole-brain relative CVR (rCVR) mapping is achieved using task-free resting-state fMRI, which resembles conventional CVR mapping using hypercapnia challenge. To optimize rCVR mapping, we apply NOise Reduction with DIstribution Corrected (NORDIC) PCA which removes thermal noise originating from the scanner and/or the subject. Results show that NORDIC-correction increases the temporal signal-to-noise ratio in both humans and mice, lowers mouse rCVR variance, and potentially improves mouse rCVR along cortical layers. Future rCVR studies investigating cerebrovascular diseases may incorporate NORDIC-correction for higher sensitivity.
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