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Abstract #3327

Benefits of echo combination for high-spatial-resolution ME resting state FMRI on a compact 3T scanner

Daehun Kang1, Myung-Ho In1, Maria A Halverson1, Nolan K Meyer1, Erin M Gray1, Thomas K Foo2, Radhika Madhavan2, Zaki Ahmed1, Hang Joon Jo3, Brice Fernandez4, David F Black1, Kirk M Welker1, Joshua D Trzasko1, John Huston, III1, Matt A Bernstein1, and Yunhong Shu1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2GE Global Research, Niskayuna, NY, United States, 3Department of Physiology, Hanyang University, Seoul, Korea, Republic of, 4GE Healthcare, Buc, France


For multi-echo EPI, the T2*-weighted echo combination (T2EC) is a commonly used pre-processing step to boost the data quality. We assessed the benefit of T2EC in high-spatial-resolution multi-echo fMRI with explained variances and functional connectivity detectability. The performance was evaluated and compared with single-echo EPI for resting state fMRI on a compact 3T scanner with high-performance gradients. It was shown that a large portion of unwanted signal variance was globally suppressed through T2EC. Multi-echo acquisition shows improved image intensity and enhanced functional sensitivity in brain regions affected by signal-dropout.

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