The simultaneous multi-slice EPI (SMS-EPI) technique is widely used in fast fMRI studies to achieve a short TR (e.g., < 1 s), but its image quality can be degraded when the slices span only a small brain area. In this study we develop a fast fMRI acquisition technique for imaging a small area by employing (k, t)-space undersampling and three-dimension reduced field-of-view imaging (k-t 3D-rFOVI). Our human fMRI experiments covering the visual cortex demonstrate that k-t 3D-rFOVI can provide higher detection sensitivity of brain activations than SMS-EPI.
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