Functional MRI (fMRI) is typically performed with whole brain coverage, even when only a small brain area is of interest. Although zoomed fMRI has been demonstrated using 2D multi-slice acquisitions, extending this capability to 3D focused volume has not been well explored. We have implemented a 3D reduced field-of-view technique for fMRI by using a 2D RF pulse and applied this technique to a visual fMRI study on ten subjects. Compared to a conventional fMRI sequence with a full field-of-view, our technique produced high isotropic spatial resolution and reduced image distortion, despite a moderate reduction in temporal signal-to-noise ratio.
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